Seven out of ten emergency physicians say emergency department violence is increasing and half have been physically assaulted at work. Not only does violence harm patient care, it is costly to hospitals.

One of the main sources of ED violence is patients diagnosed with acute agitation and aggression, which accounts for approximately 10% of emergency room visits. Common causes include alcohol and drug use, mental illness, and dementia.

When these patients demonstrate violent behavior, it not only harms care providers, it also harms them. The underlying cause of their agitation and aggression cannot be diagnosed until they are calm. When trying to sedate these patients, minutes matter.

Current Treatment Options are Unpredictable or Slow

The two most common treatments for emergency sedation today are intramuscular injection of diazepam or lorazepam. Diazepam is a fast-acting injectable sedative with optimal 2-4 hour duration of action, allowing timely re-evaluation of the patient’s condition. Diazepam, however, is highly lipophilic, which causes unpredictable absorption and onset of action when injected intramuscularly.

Lorazepam has a more predictable onset of action making it the preferred treatment for acute agitation and aggression. While it’s onset of action is predictable, it is also slow. It can take up to 40 minutes to start working and its longer duration of action means patients cannot be re-evaluated in a timely manner.

When surveyed, emergency physicians stated that rapid onset of action and safety are the largest unmet needs for sedatives in emergency setting. Physicians and nurses also seek medications with reliable and predictable performance with well-established safety profiles.

Our Diazepam Pro-Drug Delivers Fast Sedation and Predictable Outcomes

Sollievo’s diazepam pro-drug has demonstrated a 75% faster onset of action and 66% faster time to peak concentration than the leading sedative, lorazepam. With a 2-4 hour duration of action, our pro-drug offers fast sedation and predictable performance.

When presented with the pro-drug’s product profile, 76% of emergency physicians state that they would prescribe the pro-drug instead of lorazepam or diazepam.

Optimizing Onset of Sedation

Sollievo's Approach Sollievo's innovative technology has demonstrated a 75% decrease in the time to peak plasma concentration and targets a 66% decrease in the onset of action compared to the leading sedative, lorazepam. With a 2-4 hour duration of sedation, Sollievo's product offers fast sedation and predictable performance. When presented with Sollievo's product profile, 76% of emergency medicine physicians said they would prescribe the product if available in 60% of their acute agitated and aggressive patients compared to only 26% for lorazepam. Sollievo's proprietary formulation technology is the first major innovation.

Let’s Improve Emergency Room Safety

Fast and predictable sedation can improve safety for healthcare workers and the patients they serve. Patients with acute agitation and aggression may receive delayed diagnosis and treatment if they are exhibiting violent behavior. Sollievo’s pro-drug is the first major innovation in injectable sedatives in over 30 years. It’s time to improve safety; it’s time to make a change.

Call us today to learn more!


1., accessed 9/15/19.

2. Gottlieb, M., Long B., Koyfman A. Approach to the Agitated Emergency Department   Patient, J. Emergency Medicine, Vol.54, No. 4; 447-457 (2018)


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